Interferon beta-1a prevented the development of clinically definite multiple sclerosis after a first demyelinating event
نویسندگان
چکیده
منابع مشابه
Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event.
BACKGROUND Most patients with multiple sclerosis initially present with a clinically isolated syndrome. Despite the fact that clinically definite multiple sclerosis will develop in up to 80 percent of these patients, the course of the disease is unpredictable at its onset and requires long-term observation or repeated magnetic resonance imaging (MRI). We investigated whether the presence of ser...
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P a t i e n t s 308 patients (mean age 28 y, 64% women) who had presented with a first neurologic episode (unifocal or multifocal involvement of the central nervous system) suggesting MS in the previous 3 months, with ≥ 1 abnormality evident during the neurologic examination and a positive magnetic resonance imaging (MRI) scan result. Exclusion criteria included immunosuppressive or immunomodul...
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Background: High dose Interferon Beta and Fingolimod are efficient in Multiple Sclerosis. Objectives: Comparison the efficacy of these two drugs in patients with treatment failure on low dose interferon beta. Materials and Methods: The MS patients (McDonald criteria 2010) with the history of unbeneficial treatment on low dose interferon beta participated in this randomized clinical trial ...
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INTRODUCTION Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Evidence suggests that MS should be treated as early as possible in order to maximize the benefit of treatment. AREAS COVERED This review details current understanding about the treatment of relapsing-remitting MS (RRMS). The pharmacological and clinical data on the use of subcutaneous (s.c.) interferon ...
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Objective: To evaluate the clinical efficacy of onceweekly intramuscular interferon beta-1a (IFN B1a, Avonex Biogen) in Iranian multiple sclerosis (MS) patients. Methods: A 12 months, single blind clinical trial conducted from January 2001 to September 2003. Eighty patients with definite MS age 20 to 50 years were allocated to two groups. The first group received 30 microgram (6MIU) IFN B1a wee...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2001
ISSN: 1356-5524
DOI: 10.1136/ebm.6.3.78